Amlodipine Tablet
Amlodipine is a compounded formulation containing Amlodipine, prepared by Mixlab for veterinary use. Available by prescription.
The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.
Veterinarians often prioritize amlodipine in cases where a patient’s blood pressure consistently exceeds established clinical ranges. While systemic hypertension can occur as a primary condition, it is frequently identified in the context of underlying issues such as chronic kidney disease or hyperthyroidism, particularly in senior cats. In these clinical scenarios, a veterinarian may select amlodipine to assist in the long-term management of vascular pressure.
At the pharmacological level, amlodipine acts by inhibiting the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle cells. By specifically targeting L-type calcium channels, the medication promotes peripheral vasodilation, which leads to a reduction in systemic vascular resistance. amlodipine’s mechanism is highly selective for vascular smooth muscle over myocardial tissue at standard clinical doses, which is why veterinarians often favor it when a reduction in blood pressure is the primary goal without significantly altering heart rate or cardiac contractility. The specific dosing and frequency of administration will be determined by your veterinarian based on your pet’s diagnostic results and overall health profile.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
While amlodipine is generally well-tolerated, pet owners should observe their animals for signs of lethargy, decreased appetite or gingival hyperplasia (overgrowth of gum tissue), which has been documented in some long-term canine patients. Because the medication promotes vasodilation, a drop in blood pressure (hypotension) can occur, potentially manifesting as weakness or collapse. If you notice any of these changes or if your pet appears unusually tired after starting the prescription, contact your veterinarian immediately to discuss a clinical evaluation.
Amlodipine is typically used with caution in patients with known liver impairment, as the medication is extensively metabolized by the liver. It is also carefully monitored when used alongside other cardiovascular prescriptions, such as ACE inhibitors or beta-blockers, as these combinations can have additive effects on blood pressure. Your veterinarian will likely recommend periodic blood pressure monitoring to ensure the medication remains appropriate for your pet's needs. Before beginning treatment, ensure your veterinarian has a complete history of all vitamins, supplements and other medications your pet is currently taking.
Yes, amlodipine is a prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all prescriptions with the prescribing veterinary office before any medication is shipped to your home.
Amlodipine is available in various commercial tablet sizes, but when a specific strength or a more palatable format like a flavored liquid or chew is needed, Mixlab can compound a custom formulation. Your veterinarian will decide if a compounded version is the best fit for your pet’s specific requirements and ease of administration.
Veterinarians typically monitor patients through regular blood pressure screenings to evaluate how the individual is responding to the medication over time. Depending on the underlying cause of the hypertension, your veterinarian may also request periodic blood work to check kidney function or other metabolic markers.
High blood pressure is often a "silent" condition, but in some cases, owners may notice sudden vision changes, dilated pupils or increased thirst and urination. Because these signs are often linked to other health issues, a veterinarian will use specialized equipment to take an accurate blood pressure reading during a clinical exam.
