Acitretin Capsule
Acitretin is a compounded formulation containing Acitretin, prepared by Mixlab for veterinary use. Available by prescription.
Use as directed by your veterinarian.
The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.
Veterinarians most commonly consider acitretin for the management of idiopathic seborrhea, particularly in breeds like the American Cocker Spaniel and for specific conditions such as sebaceous adenitis or cutaneous lymphoma. It is also frequently a point of discussion for cases of solar-induced lesions or certain types of hyperkeratotic skin diseases where topical interventions are not sufficient. By modulating how skin cells replicate and mature, your veterinarian can manage the physiological state of the pet’s skin surface.
At a pharmacological level, acitretin acts by binding to specific nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs) within skin cells. This binding influences gene expression, which results in the normalization of cell proliferation and differentiation. Furthermore, acitretin has been studied for its ability to exert anti-inflammatory and immunomodulatory effects within the dermis. Your veterinarian will determine whether acitretin is appropriate based on the results of a skin biopsy, blood work and the specific clinical nature of your pet's prescriptions and health history.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of acitretin administration include dry skin, redness, peeling and crusting, particularly around the eyes and mouth. Some animals may experience a decrease in tear production (dry eye), hair loss or localized irritation. Because acitretin is metabolized by the liver, your veterinarian will monitor for shifts in hepatic health and may recommend periodic blood work to evaluate liver enzymes and triglyceride levels throughout the protocol. Owners should watch for signs of lethargy, vomiting or significant changes in appetite and contact their veterinarian promptly if these occur.
This medication is typically used with extra caution or avoided in patients with known liver disease, kidney impairment or pre-existing cardiovascular challenges. Acitretin is highly teratogenic, meaning it can cause severe birth defects; therefore, it is strictly avoided in pregnant animals or those intended for breeding. Before starting a protocol, ensure your veterinarian has a complete history of all other supplements and medications your pet is receiving, as acitretin may interact with Vitamin A supplements, certain antibiotics or other retinoids. Your veterinarian is the right person to provide guidance on the necessary duration of use and the most appropriate monitoring plan to ensure the management approach remains suitable for your pet's individual health status.
Yes. Acitretin is a potent prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all authorizations before any medication is prepared or shipped to your home.
Yes. While acitretin is available as a commercial capsule, Mixlab can compound this medication into specialized strengths or alternative flavored dosage forms if your veterinarian determines a customized preparation better suits your pet's needs. The decision between a commercial and compounded product rests with the prescribing veterinarian.
Veterinarians commonly consider acitretin for disorders of keratinization, such as idiopathic seborrhea, sebaceous adenitis and certain types of skin cancer like cutaneous lymphoma. Its use is determined by a licensed veterinarian based on the patient's individual diagnostic results and overall health profile.
Because acitretin can influence liver function and blood lipid levels, veterinarians typically recommend periodic blood work to monitor liver enzymes, cholesterol and triglycerides. These diagnostic follow-ups allow your veterinarian to ensure the management plan remains appropriate for your pet's internal health.
