3-D Cream (Diclofenac Sodium, Dexamethasone, DMSO) Cream
3-D Cream is a compounded topical cream containing diclofenac sodium, dexamethasone and DMSO, prepared by Mixlab for veterinary use in horses. Available by prescription.
How to Apply Topical Cream to Your Pet
Topical creams are smooth, lotion-like medications applied to your pet’s skin to treat infections, wounds, or deliver medicine. Here’s a simple step-by-step guide:
- Prep Yourself: Wash your hands first. Use gloves if advised by your vet.
- Prep the Area: Clean the affected area gently with warm water and pat dry. If needed, part or trim fur to reach the skin (only if your vet recommends).
- Apply the Cream: Use the prescribed amount (usually pea-sized). Apply directly to the skin.
- Spread It Gently: Rub the cream in softly to create a thin, even layer.
- Prevent Licking: Distract your pet or use a cone to stop licking until the cream absorbs.
- Clean Up: Wash your hands (and discard gloves, if used).
- Follow-Up: Reward your pet! Monitor the area and contact your vet if irritation appears.
3-D Cream is a compounded topical cream combining diclofenac sodium (an NSAID), dexamethasone (a corticosteroid) and DMSO (a penetration enhancer). In compounding practice, clinicians may consider a topical combination like this when a localized approach is preferred over systemic administration. Your veterinarian determines whether it is appropriate for your horse.
The three components act through different mechanisms. Diclofenac sodium is an NSAID that inhibits the cyclooxygenase (COX) enzymes involved in producing pro-inflammatory prostaglandins. Dexamethasone is a corticosteroid that modulates the immune response and inflammatory mediators at the cellular level. DMSO is a solvent and penetration enhancer that alters the permeability of the skin barrier, helping the other ingredients reach deeper tissues.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of 3-D Cream include localized skin irritation, redness or dryness at the site of application. Because DMSO can carry other substances through the skin, it is essential that the application area is clean and free of other chemicals or contaminants before use. Some horses may exhibit a garlic-like odor on their breath or skin following the use of DMSO-based products. Owners should wear gloves during administration to prevent accidental absorption, as the ingredients can be absorbed through human skin as well.
This medication is typically used with extra caution or avoided in patients with known hypersensitivity to NSAIDs, corticosteroids or DMSO. It may be contraindicated in horses with existing renal or hepatic compromise or in those with active skin infections at the intended application site. Because corticosteroids like dexamethasone can affect metabolic and immune function, your veterinarian will monitor for systemic effects, particularly during prolonged use. Always consult with your veterinarian regarding the appropriate duration of use and whether your horse's competitive status requires a withdrawal period. Both dexamethasone (a corticosteroid) and diclofenac (an NSAID) are subject to detection in equine medication-testing programs and specific withdrawal times vary by jurisdiction and governing body.
Yes. 3-D Cream contains regulated medications including a corticosteroid and an NSAID, which require a valid prescription from a licensed veterinarian. Mixlab complies with all state and federal regulations by verifying authorization before dispensing any prescription product.
Yes, 3-D Cream is a compounded topical preparation. When a veterinarian determines that this specific combination of diclofenac, dexamethasone and DMSO is the most appropriate management approach for a horse, Mixlab’s compounding team prepares the cream to meet those specific clinical requirements.
DMSO is included in 3-D Cream primarily because of its ability to act as a penetration enhancer. In veterinary medicine, it is frequently used in topical formulations to help other active medications, such as NSAIDs and steroids, pass through the skin barrier to reach deeper tissues.
Yes. Owners should wear protective gloves when applying 3-D Cream, because DMSO can carry substances through human skin. Make sure the horse's skin is clean and dry before applying, so the DMSO does not carry dirt or other chemicals into the skin.
Diclofenac is an NSAID available in a topical form. A topical application delivers the ingredient to a specific area rather than throughout the body. Your veterinarian determines whether a topical or another approach is appropriate for your horse.
